Mechanisms of bone pain: Progress in research from bench to bedside
The field of research on pain originating from various bone diseases is expanding rapidly,
with new mechanisms and targets asserting both peripheral and central sites of action. The …
with new mechanisms and targets asserting both peripheral and central sites of action. The …
Recent advances in pain management based on nanoparticle technologies
S Babaie, A Taghvimi, JH Hong… - Journal of …, 2022 - Springer
Background Pain is a vital sense that indicates the risk of injury at a particular body part.
Successful control of pain is the principal aspect in medical treatment. In recent years, the …
Successful control of pain is the principal aspect in medical treatment. In recent years, the …
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain
Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects
and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for …
and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for …
Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats
Opioids are employed in the management of chemotherapy-induced neuropathic pain
(CINP) when other pain management approaches have failed and proven ineffective …
(CINP) when other pain management approaches have failed and proven ineffective …
John J. Bonica Award Lecture: Peripheral neuronal hyperexcitability: the “low-hanging” target for safe therapeutic strategies in neuropathic pain
SN Raja, M Ringkamp, Y Guan, JN Campbell - Pain, 2020 - journals.lww.com
Neuropathic pain (NP) results from injury to or disease of the somatosensory system. It is
estimated that approximately 7% to 10% of the population and 25% to 30% of individuals …
estimated that approximately 7% to 10% of the population and 25% to 30% of individuals …
Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents
Several reports support the idea that m-and d-opioid receptors (ORs) may exist as
heterodimers in brain regions involved in pain signaling. The unique pharmacology of these …
heterodimers in brain regions involved in pain signaling. The unique pharmacology of these …
Endogenous opiates and behavior: 2016
RJ Bodnar - Peptides, 2018 - Elsevier
This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …
concerning the endogenous opioid system. It summarizes papers published during 2016 …
Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources
Strong opioid analgesics, including morphine, are the mainstays for treating moderate to
severe acute pain and alleviating chronic cancer pain. However, opioid-related adverse …
severe acute pain and alleviating chronic cancer pain. However, opioid-related adverse …
Sex differences in gene regulation in the dorsal root ganglion after nerve injury
Background Pain is a subjective experience derived from complex interactions among
biological, environmental, and psychosocial pathways. Sex differences in pain sensitivity …
biological, environmental, and psychosocial pathways. Sex differences in pain sensitivity …
Astaxanthin ameliorates behavioral and biochemical alterations in in-vitro and in-vivo model of neuropathic pain
K Sharma, D Sharma, M Sharma, N Sharma, P Bidve… - Neuroscience …, 2018 - Elsevier
Despite considerable advances in understanding mechanisms involved in chronic pain,
effective treatment remains limited. Astaxanthin, a marine natural drug, having potent anti …
effective treatment remains limited. Astaxanthin, a marine natural drug, having potent anti …