[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Current state and future perspective of cardiovascular medicines derived from natural products

C Zhao, S Li, J Zhang, Y Huang, L Zhang… - Pharmacology & …, 2020 - Elsevier
The contribution of natural products (NPs) to cardiovascular medicine has been extensively
documented, and many have been used for centuries. Cardiovascular disease (CVD) is the …

Plasma pharmacokinetics of (poly) phenol metabolites and catabolites after ingestion of orange juice by endurance trained men

G Pereira-Caro, MN Clifford, T Polyviou… - Free Radical Biology …, 2020 - Elsevier
The health benefits of orange juice (OJ) consumption are attributed in part to the circulating
flavanone phase II metabolites and their microbial-derived ring fission phenolic catabolites …

[HTML][HTML] Ex vivo fecal fermentation of human ileal fluid collected after raspberry consumption modifies (poly) phenolics and modulates genoprotective effects in colonic …

S Dobani, C Latimer, GJ McDougall, JW Allwood… - Redox biology, 2021 - Elsevier
Diets rich in fruit and vegetables are associated with a decreased incidence of colorectal
cancer (CRC) due, in part, to the bioactive (poly) phenolic components and their microbiota …

[HTML][HTML] The role of flavonoids in the prevention and management of cardiovascular complications: A narrative review

Z Chen, SL Zhang - Annals of palliative medicine, 2021 - apm.amegroups.org
Objective: Cardiovascular diseases (CVDs) are the world's leading cause of death, affecting
an estimated 17.9 million people. CVDs have been the primary risk factor for mortality in …

[HTML][HTML] How hesperidin and Hesperetin, as promising food Supplements, combat cardiovascular Diseases: A systematic review from bench to bed

SN Khalilabad, A Mirzaei, VR Askari, A Mirzaei… - Journal of Functional …, 2024 - Elsevier
This investigation aims to determine how hesperidin and hesperetin, natural flavonoids
found abundantly in citrus fruits, affect cardiovascular diseases. From inception until January …

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalcones via palladium (ii)-catalyzed oxidative cyclization

SH Son, YY Cho, HS Yoo, SJ Lee, YM Kim, HJ Jang… - RSC …, 2021 - pubs.rsc.org
Divergent and versatile synthetic routes to flavones and flavanones via efficient Pd (II)
catalysis are disclosed. These Pd (II) catalyses expediently provide a variety of flavones and …

Essential oil composition, antioxidant activity, phenolic compounds, total phenolic and flavonoid contents from pomace of Citrus aurantifolia

H Tavallali, A Bahmanzadegan… - Journal of Medicinal …, 2021 - jmpb.areeo.ac.ir
The massive pomace of Citrus aurantofolia (Christm.) Swingle exhibits a challenging losses
exposure difficulty for the processing industries. The resent study was aimed to evaluate the …

Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca2+ homeostasis

P Liu, J Chen, J Qi, M Liu, M Zhang, Y Xue… - Phytotherapy …, 2023 - Wiley Online Library
Abstract Ischemia/hypoxia (I/H)‐induced myocardial injury has a large burden worldwide.
Hesperetin (HSP) has a cardioprotective effect, but the molecular mechanism underlying this …

Benzopyrone, a privileged scaffold in drug discovery: An overview of FDA‐approved drugs and clinical candidates

V Sharma, A Sharma, BN Wadje… - Medicinal Research …, 2024 - Wiley Online Library
Natural products have always served as an important source of drugs for treating various
diseases. Among various privileged natural product scaffolds, the benzopyrone class of …