[PDF][PDF] The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis
RAD Castro, S Borrell, S Gagneux - FEMS microbiology reviews, 2021 - academic.oup.com
Tuberculosis (TB) has been responsible for the greatest number of human deaths due to an
infectious disease in general, and due to antimicrobial resistance (AMR) in particular. The …
infectious disease in general, and due to antimicrobial resistance (AMR) in particular. The …
Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms
CRyPTIC Consortium - PLoS biology, 2022 - journals.plos.org
The emergence of drug-resistant tuberculosis is a major global public health concern that
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …
In-host population dynamics of Mycobacterium tuberculosis complex during active disease
Tuberculosis (TB) is a leading cause of death globally. Understanding the population
dynamics of TB's causative agent Mycobacterium tuberculosis complex (Mtbc) in-host is vital …
dynamics of TB's causative agent Mycobacterium tuberculosis complex (Mtbc) in-host is vital …
Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences
Background Mycobacterium tuberculosis whole genome sequencing (WGS) data can
provide insights into temporal and geographical trends in resistance acquisition and inform …
provide insights into temporal and geographical trends in resistance acquisition and inform …
[HTML][HTML] Towards standardisation: comparison of five whole genome sequencing (WGS) analysis pipelines for detection of epidemiologically linked tuberculosis cases
Background Whole genome sequencing (WGS) is a reliable tool for studying tuberculosis
(TB) transmission. WGS data are usually processed by custom-built analysis pipelines with …
(TB) transmission. WGS data are usually processed by custom-built analysis pipelines with …
Genomic variant-identification methods may alter Mycobacterium tuberculosis transmission inferences
Pathogen genomic data are increasingly used to characterize global and local transmission
patterns of important human pathogens and to inform public health interventions. Yet, there …
patterns of important human pathogens and to inform public health interventions. Yet, there …
Transmission, distribution and drug resistance-conferring mutations of extensively drug-resistant tuberculosis in the Western Cape Province, South Africa
S Oostvogels, SD Ley, TH Heupink… - Microbial …, 2022 - microbiologyresearch.org
Extensively drug-resistant tuberculosis (XDR-TB), defined as resistance to at least isoniazid
(INH), rifampicin (RIF), a fluoroquinolone (FQ) and a second-line injectable drug (SLID), is …
(INH), rifampicin (RIF), a fluoroquinolone (FQ) and a second-line injectable drug (SLID), is …
Prolonged survival of a patient with active MDR-TB HIV co-morbidity: insights from a Mycobacterium tuberculosis strain with a unique genomic deletion
M Rubinstein, A Makhon, Y Losev, GZ Valenci… - Frontiers in …, 2023 - frontiersin.org
Coinfection of HIV and multidrug-resistant tuberculosis (MDR-TB) presents significant
challenges in terms of the treatment and prognosis of tuberculosis, leading to complexities in …
challenges in terms of the treatment and prognosis of tuberculosis, leading to complexities in …
Exploring the resistome, virulome, and mobilome of multidrug-resistant Klebsiella pneumoniae isolates: deciphering the molecular basis of carbapenem resistance
S Rahmat Ullah, S Irum, I Mahnoor, H Ismatullah… - BMC genomics, 2024 - Springer
Background Klebsiella pneumoniae, a notorious pathogen for causing nosocomial
infections has become a major cause of neonatal septicemia, leading to high morbidity and …
infections has become a major cause of neonatal septicemia, leading to high morbidity and …
Evaluation of whole-genome sequence to predict drug resistance of nine anti-tuberculosis drugs and characterize resistance genes in clinical rifampicin-resistant …
Y Che, Y Lin, T Yang, T Chen, G Sang… - Frontiers in Public …, 2022 - frontiersin.org
Setting Controlling drug-resistant tuberculosis in Ningbo, China. Objective Whole-genome
sequencing (WGS) has not been employed to comprehensively study Mycobacterium …
sequencing (WGS) has not been employed to comprehensively study Mycobacterium …