Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …

Alzheimer's disease (AD) is the most common dementing disorder of late life. Although there
might be various different triggering events in the early stages of the disease, they seem to …

While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not
been demonstrated directly in that disorder. We provide such a demonstration here by …

Alzheimer's disease (AD) and diabetes are currently considered among the top threats to
human health worldwide. Intriguingly, a connection between these diseases has been …

Recent work has suggested that exercise may be beneficial in preventing or ameliorating
symptoms of several neurological disorders, although the mechanism is not entirely …

Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD).
Most AD cases are sporadic and result from multiple etiologic factors, including …

Insulin signaling in central nervous system (CNS) has emerged as a novel field of research
since decreased brain insulin levels and/or signaling were associated to impaired learning …

The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …

Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …

Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by
impairments of cognitive function as a result of synaptic deficits and neuronal loss, is …