The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in …
Two genomic contigs of putative growth hormone receptors (GHRs) were identified in fugu
and zebrafish genomes by in silico analysis, suggesting the presence of two GHR subtypes …
and zebrafish genomes by in silico analysis, suggesting the presence of two GHR subtypes …
Curcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway
Y Sun, L Liu, Y Wang, A He, H Hu, J Zhang… - OncoTargets and …, 2019 - Taylor & Francis
Purpose The aims of this study were to determine the effect of curcumin on osteosarcoma
(OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic …
(OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic …
Growth hormone: does it have a therapeutic role in fracture healing?
GT Tran, J Pagkalos, E Tsiridis, AA Narvani… - Expert opinion on …, 2009 - Taylor & Francis
Background: The role of growth hormone (GH) in augmenting fracture healing has been
postulated for over half a century. GH has been shown to play a role in bone metabolism …
postulated for over half a century. GH has been shown to play a role in bone metabolism …
Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling
Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of
prostate cancer deaths with the median survival after diagnosis being 2 years. The …
prostate cancer deaths with the median survival after diagnosis being 2 years. The …
MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs
YH Joung, EJ Lim, P Darvin, SC Chung, JW Jang… - 2012 - journals.plos.org
Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound with well-known anti-
oxidant properties and anti-inflammatory activities. But, its effects on bone are unknown …
oxidant properties and anti-inflammatory activities. But, its effects on bone are unknown …
Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor α homodimers
T Hornakova, J Staerk, Y Royer, E Flex… - Journal of Biological …, 2009 - ASBMB
Activating mutations in JAK1 have been reported in acute lymphoblastic leukemias, but little
is known about the mechanisms involved in their constitutive activation. Here, we studied the …
is known about the mechanisms involved in their constitutive activation. Here, we studied the …
Distinct acute lymphoblastic leukemia (ALL)-associated Janus kinase 3 (JAK3) mutants exhibit different cytokine-receptor requirements and JAK inhibitor specificities
E Losdyck, T Hornakova, L Springuel, S Degryse… - Journal of Biological …, 2015 - ASBMB
JAK1 and JAK3 are recurrently mutated in acute lymphoblastic leukemia. These tyrosine
kinases associate with heterodimeric cytokine receptors such as IL-7 receptor or IL-9 …
kinases associate with heterodimeric cytokine receptors such as IL-7 receptor or IL-9 …
Stimulation of ERK2 by taurine with enhanced alkaline phosphatase activity and collagen synthesis in osteoblast-like UMR-106 cells
S Park, H Kim, SJ Kim - Biochemical pharmacology, 2001 - Elsevier
Taurine is present in a variety of tissues and exhibits many important physiological functions
in the cell. Even though its functions are well documented in many tissues, its actions on …
in the cell. Even though its functions are well documented in many tissues, its actions on …
Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors
L Springuel, T Hornakova, E Losdyck… - Blood, The Journal …, 2014 - ashpublications.org
The acquisition of growth signal self-sufficiency is 1 of the hallmarks of cancer. We
previously reported that the murine interleukin-9–dependent TS1 cell line gives rise to …
previously reported that the murine interleukin-9–dependent TS1 cell line gives rise to …
Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells
E Mrak, I Villa, R Lanzi, M Losa… - Journal of …, 2007 - joe.bioscientifica.com
It is presently thought that osteoprotegerin (OPG) is a cytokine involved in the regulation of
osteoblast/osteoclast crosstalk and maintenance of bone mass. Recent studies showed that …
osteoblast/osteoclast crosstalk and maintenance of bone mass. Recent studies showed that …