Granules are essential for the ability of neutrophils to fulfill their role in innate immunity.
Granule membranes contain proteins that react to environmental cues directing neutrophils …

Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …

First identified as a neutrophil granule component, neutrophil gelatinase-associated
lipocalin (NGAL; also called human neutrophil lipocalin, 24p3, uterocalin, or neu-related …

Fig 2. Classification of granules in neutrophils. Peroxidase-positive (azurophilic or primary)
granules are characterized by the content of MPO and may be further divided based on their …

The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and
secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the …

Staphylococcus aureus has been an important human pathogen throughout history and is
currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability …

Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes …

Neutrophils are the first line of innate immune defense against infectious diseases.
However, since their discovery by Elie Metchnikoff, they have always been considered …

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa lipocalin first identified as a
protein stored in specific granules of the human neutrophil. The protein is believed to bind …

Neutrophils constitute the dominant cell in the circulation that mediates the earliest innate
immune human responses to infection. The morbidity and mortality from infection rise …