Studies with temporal or spatial resolution are crucial to understand the molecular dynamics
and spatial dependencies underlying a biological process or system. With advances in high …

Neural activity is both a driver of brain development and a readout of developmental
processes. Changes in neuronal activity are therefore both the cause and consequence of …

Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species
comparisons have been largely restricted to adult tissues and the functionality of most AS …

Sexually dimorphic traits are common among mammals and are specified during
development through the deployment of sex-specific genetic programs. Because little is …

The expansion of the neocortex, a hallmark of mammalian evolution,, was accompanied by
an increase in cerebellar neuron numbers. However, little is known about the evolution of …

Abstract TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are
recognised as a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. As …

Fibroblasts are the primary regulator of cardiac extracellular matrix (ECM). In response to
disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast …

Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the
field of in vitro disease modeling, granting us access to disease-pertinent human cells of the …

The use of standardised phenotyping screens to identify abnormal phenotypes in mouse
knockouts, together with the use of ontologies to describe such phenotypic features, allows …

Background The correlations between genetic risk for Alzheimer's disease (AD) with
comprehensive brain regions at a regional scale are still not well understood. We aim to …