Sickle cell disease (SCD) is one of the most common genetic causes of illness and death in
the world. This is a review of SCD in Africa, which bears the highest burden of disease. The …

Sickle cell disease (SCD) predominates in sub‐Saharan Africa, East Mediterranean areas,
Middle East, and India. Nigeria, being the most populous black nation in the world, bears its …

Approximately 280 000 children are born with sickle cell anemia (SCA) in Africa annually,
yet few survive beyond childhood. Falciparum malaria is considered a significant cause of …

Asymptomatic malaria parasite carriers do not seek anti-malarial treatment and may
constitute a silent infectious reservoir. In order to assess the level of asymptomatic and …

Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …

Sickle cell disease (SCD) is a chronic debilitating disorder affecting erythrocytes, which is
especially prevalent throughout Sub‐S aharan A frica and among individuals of A frican …

Efavirenz and proguanil are likely to be administered concurrently for the treatment of
patients with HIV and malaria. The metabolism of proguanil is mediated principally by …

Background Several studies have shown that the pathophysiology of homozygous sickle cell
anaemia (SCA) results in a myriad of metabolic, nutritional, haematological and clinical …

The self-care management of sickle cell disease (SCD) improves mortality rate; however,
compliance with SCD self-care management remains a problem. The purpose of this study …

Abstract Background: Transfusion of RBCs is a major therapeutic option for anemia in
homozygous SCD. Numerous studies conducted in the world to determine the frequency of …