A second space age spanning omics, platforms and medicine across orbits

CE Mason, J Green, KI Adamopoulos, EE Afshin… - Nature, 2024 - nature.com
The recent acceleration of commercial, private and multi-national spaceflight has created an
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …

[PDF][PDF] Protective alleles and precision healthcare in crewed spaceflight

LA Rutter, MJ MacKay, H Cope, NJ Szewczyk… - Nature …, 2024 - nature.com
Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

EG Overbey, K Ryon, JK Kim, BT Tierney… - Nature …, 2024 - nature.com
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses

K Grigorev, TM Nelson, EG Overbey, N Houerbi… - Nature …, 2024 - nature.com
The advent of civilian spaceflight challenges scientists to precisely describe the effects of
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

JS Garcia-Medina, K Sienkiewicz… - Precision Clinical …, 2024 - academic.oup.com
Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight mission,
investigated the physiological effects of short-duration spaceflight through a multi-omic …

Toward Next-Generation Phenomics: Precision Medicine, Spaceflight, Astronaut Omics, and Beyond

V Özdemir - OMICS: A Journal of Integrative Biology, 2024 - liebertpub.com
Large investments over many decades in genomics in diverse fields such as precision
medicine, plant biology, and recently, in space life science research and astronaut omics …

Bridging Earth and Space: A Flexible and Resilient Federated Learning Framework Deployed on the International Space Station

JA Casaletto, P Foley, M Fernandez, LM Sanders… - bioRxiv, 2025 - biorxiv.org
The public and commercial space industries are planning longer duration and more distant
space missions, including the establishment of a habitable lunar base and crewed missions …

Space Medicine and Research Industry, Innovation, and Infrastructure

A Bhardwaj, S Sharma - … and Challenges in Space Medicine and …, 2025 - igi-global.com
Abstract Space medicine and research represent pioneering frontiers in healthcare and
scientific exploration, focusing on the unique challenges and opportunities presented by …

[PDF][PDF] Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and …

JA Casaletto, P Foley, M Fernandez, LM Sanders… - fdl.ai
The public and commercial space industries are planning longer duration and more distant
space missions, including the establishment of a habitable lunar base and crewed missions …