There are currently more than 15 million cancer survivors in the United States, and it is
estimated that with improved treatment and early detection, the number of cancer survivors …

Purpose Understanding the etiology of cancer-related fatigue (CRF) is critical to identify
targets to develop therapies to reduce CRF burden. The goal of this systematic review was …

Previous studies have reported that 15% to 25% of patients treated for breast cancer
experience long-term moderate-to-severe pain in the area of surgery, potentially lasting for …

In human studies, low COMT (catechol-O-methyltransferase) activity has been associated
with increased sensitivity to acute clinical preoperative or postoperative pain. We explored …

Fatigue, which is one of the most commonly reported symptoms in cancer, can negatively
impact the functional status and the health-related quality of life of individuals. This paper …

Persistent pain after breast cancer surgery (PPBCS) is increasingly recognized as a
potential problem facing a sizeable subset of the millions of women who undergo surgery as …

The catechol-O-methyltransferase (COMT) gene has arguably been the designated pain
sensitivity gene for nearly two decades. However, the literature provides inconsistent …

Genetic interactions between catechol-O-methyltransferase val 158 met with estrogen
receptor 1 and guanosine-5-triphosphate cyclohydrolase 1 polymorphisms modulate …

Purpose Cancer-related fatigue (CRF) is the most common symptom experienced by cancer
survivors. It is a multidimensional symptom affecting physical, emotional, and/or cognitive …

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