Redox stress and signaling during vertebrate embryonic development: Regulation and responses

AR Timme-Laragy, ME Hahn, JM Hansen… - Seminars in cell & …, 2018 - Elsevier
Vertebrate embryonic development requires specific signaling events that regulate cell
proliferation and differentiation to occur at the correct place and the correct time in order to …

Environmental toxicant exposures and type 2 diabetes mellitus: two interrelated public health problems on the rise

MG Bonini, RM Sargis - Current opinion in toxicology, 2018 - Elsevier
Rates of type 2 diabetes mellitus (T2DM) are rising rapidly across the globe and the impact
of this devastating disease threatens to plague the 21st century. While some contributing …

Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated …

TH Lu, TJ Tseng, CC Su, FC Tang, CC Yen, YY Liu… - Toxicology letters, 2014 - Elsevier
Abstract Arsenic (As), a well-known high toxic metal, is an important environmental and
industrial contaminant, and it induces oxidative stress, which causes many adverse health …

Selenium alleviates pancreatic fibrosis in chickens caused by mercuric chloride: Involvement of the MAPK signaling pathway and selenoproteins

Y Li, H Cui, D Li, HY Fu, JZ Li, WX Xu, RF Fan - Environmental Pollution, 2024 - Elsevier
Mercuric chloride (HgCl 2) is a widespread inorganic mercury with digestive toxicity. The
pancreas is an important digestive organ in animals, and pancreatic fibrosis (PF) is a major …

Methylmercury induces mitochondria-and endoplasmic reticulum stress-dependent pancreatic β-cell apoptosis via an oxidative stress-mediated JNK signaling …

CY Yang, SH Liu, CC Su, KM Fang, TY Yang… - International journal of …, 2022 - mdpi.com
Methylmercury (MeHg), a long-lasting organic pollutant, is known to induce cytotoxic effects
in mammalian cells. Epidemiological studies have suggested that environmental exposure …

Evidence of the different effect of mercury and cadmium on the hIAPP aggregation process

D Meleleo, A Gerbino, M Mastrodonato - Biophysical Chemistry, 2022 - Elsevier
Abstract hIAPP is a hormone consisting of 37 aminoacids that shows a strong tendency to
self-assemble into β-sheet-rich aggregates, which evolve to form insoluble aggregates that …

[HTML][HTML] Type 2 diabetes occurrence and mercury exposure–From the National Nutrition and Health Survey in Taiwan

TL Tsai, CC Kuo, WH Pan, TN Wu, P Lin… - Environment …, 2019 - Elsevier
Background The global prevalence of type 2 diabetes continues to increase in both
developed and developing countries. Environmental exposure to mercury may be an …

Intermittent fasting for twelve weeks leads to increases in fat mass and hyperinsulinemia in young female Wistar rats

AC Munhoz, EA Vilas-Boas, AC Panveloski-Costa… - Nutrients, 2020 - mdpi.com
Fasting is known to cause physiological changes in the endocrine pancreas, including
decreased insulin secretion and increased reactive oxygen species (ROS) production …

Chronic mercury at low doses impairs white adipose tissue plasticity

DA Rizzetti, P Corrales, JT Piagette, JA Uranga-Ocio… - Toxicology, 2019 - Elsevier
Introduction The toxic effects of mercury (Hg) are involved in homeostasis of energy systems
such as lipid and glucose metabolism, and white adipose tissue dysfunction is considered …

Effects of methyl mercury on the activity and gene expression of mouse Langerhans islets and glucose metabolism

F Maqbool, H Bahadar, K Niaz, M Baeeri… - Food and Chemical …, 2016 - Elsevier
Mercury (Hg) is a well-known heavy metal and causes various toxic effects. It is abundantly
present in fish in the form of methyl mercury (MeHg). Also, various other forms of mercury …