Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

Because genetic alterations including mutations, overexpression, translocations, and
dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this …

Owing to the dysregulation of protein kinase activity in many diseases including cancer, the
protein kinase enzyme family has become one of the most important drug targets in the 21st …

Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

Objective JAK inhibitor therapies are effective treatment options for immune‐mediated
inflammatory diseases (IMIDs), but their use has been limited by venous thromboembolism …

Because genetic alterations including mutations, overexpression, translocations, and
dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this …

Novel agents addressing non-amyloid, non-tau targets in Alzheimer's Disease (AD)
comprise 70% of the AD drug development pipeline of agents currently in clinical trials. Most …

Vascular pathologies underpin and intertwine autoimmune rheumatic diseases and
cardiovascular conditions, and atherosclerosis is increasingly recognized as the leading …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
serves as a paradigm for signal transduction from the extracellular environment to the …

Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or
ACPA positive) and seronegative subsets. Methods We performed a genome-wide …