Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Abstract A Disintegrin and Metalloproteinase (ADAM) is a family of proteolytic enzymes that
possess sheddase function and regulate shedding of membrane-bound proteins, growth …

Morphological characteristics and source of adipose tissue as well as adipokines may
increase cardiometabolic risk. This study aimed to explore whether adipose tissue …

Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized
by the inflammation of the bone leading to degeneration and loss of cartilage function …

Significance: The vascular extracellular matrix (ECM) not only provides mechanical stability
but also manipulates vascular cell behaviors, which are crucial for vascular function and …

Normal pregnancy (NP) involves intricate processes starting with egg fertilization,
proceeding to embryo implantation, placentation and gestation, and culminating in …

ADAMTS18 was identified in 2002 as a member of the ADAMTS family of 19 secreted Zinc-
dependent metalloproteinases. Prior to 2016, ADAMTS18 was known as a candidate gene …

Estrogens and progesterone control breast development and carcinogenesis via their
cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How …

The distinct anatomic environment in which adipose tissues arise during organogenesis is a
principle determinant of their adult expansion capacity. Metabolic disease results from a …

Background Human epidermal growth factor receptor 2 (HER2)-positive breast cancer
accounts for about 20% of all breast cancer cases and is correlated with a high relapse rate …