Detection of minimal residual disease (MRD) has proven to provide independent prognostic
information for treatment stratification in several types of leukemias such as childhood acute …

Because of developments in diagnosis of haemopoietic malignant diseases during the past
two decades, routine and reliable identification of very low numbers of malignant cells …

Biomarkers are molecular indicators of a biological status, and as biochemical species can
be assayed to evaluate the presence of cancer and therapeutic interventions. Through a …

Abstract 16; 21 translocation is a recurrent primary abnormality in acute myeloid leukemia
(AML). The genes involved in this translocation are ERG on chromosome 21 and TLS/FUS …

Acute myeloid leukaemia (AML) has been proposed to arise from the collaboration between
two classes of mutation, a class I, or proliferative, mutation and a class II, or blocking …

PURPOSE: To prospectively compare cytogenetics and reverse transcriptase–polymerase
chain reaction (RT-PCR) for detection of t (8; 21)(q22; q22) and inv (16)(p13q22)/t (16; …

The proteins known as the polyoma enhancer binding protein 2 or core-binding factor
(PEBP2/CBF) are heterodimeric transcription factors that contain a DNA-binding subunit …

Relapse is the main cause of treatment failure after allogeneic haematopoietic stem cell
transplantation (allo‐HSCT) for acute leukaemia (AL). Post‐transplantation minimal residual …

Inv (16)(p13q22) is one of the most frequent chromosomal rearrangements found in acute
myelogenous leukemia (AML), representing approximately 16% of documented karyotypic …

Amplification of the CBFβ/MYH11 fusion transcript by a qualitative reverse transcription-
polymerase chain reaction (RT-PCR) has been used to detect minimal residual disease …