Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among
which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile …

Long RNAs vary extensively in their post-transcriptional fates, and this variation is attributed
in part to short sequence elements. We used massively parallel RNA assays to study how …

Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent
changes in plasticity. Here, we develop a strategy combining compartment-specific …

RNA granules are dynamic entities controlling the spatiotemporal distribution and translation
of RNA molecules. In neurons, a variety of RNA granules exist both in the soma and in …

Highlights•Proteostasis is the balance between protein synthesis and degradation and is
perturbed in neurodevelopmental disorders.•Several genes associated with NDDs lead to …

Gene expression is tightly regulated by RNA-binding proteins (RBPs) to facilitate cell
survival, differentiation, and migration. Previous reports have shown the importance of the …

The biological role of RNA-binding proteins in the secretory pathway is not well established.
Here, we describe that human HDLBP/Vigilin directly interacts with more than 80% of ER …

Biomolecular condensates have recently retained much attention given that they provide a
fundamental mechanism of cellular organization. Among those, cytoplasmic …

Despite sustained efforts to treat neurodegenerative diseases, little is known at the
molecular level to understand and generate novel therapeutic approaches for these …