Introduction The treatment algorithm of advanced hepatocellular carcinoma (HCC) has
evolved since the introduction of immunotherapy. The IMbrave150 trial set atezolizumab …

Osteosarcoma, one of the common malignant tumors in the skeletal system, originates in
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …

Radiation therapy (RT) activates an in situ vaccine effect when combined with immune
checkpoint blockade (ICB), yet this effect may be limited because RT does not fully optimize …

Taxanes remain one of the most effective medical treatments for breast cancer. Clinical trials
have coupled taxanes with immune checkpoint inhibitors in patients with triple-negative …

Oncogenes destabilize STING in epithelial cell-derived cancer cells, such as head and neck
squamous cell carcinomas (HNSCCs), to promote immune escape. Despite the abundance …

Stimulator of interferon gene (STING), an intracellular receptor in the endoplasmic reticulum,
could induce the production of cytokines such as type I interferon (IFN) by activating the …

The advancement of theranostics, which combines therapeutic and diagnostic capabilities in
oncology, has significantly impacted cancer management. This review explores fibroblast …

Preclinical models of cancer have long been paramount to understanding tumor
development and advancing the treatment of cancer. Creating preclinical models that mimic …

Background Radiation therapy (RT) elicits DNA double-strand breaks, resulting in tumor
cytotoxicity and a type I interferon (IFN) response via stimulator of interferon genes (STING) …

The development of immunotherapy, in particular immune checkpoint inhibitors (ICI), has
revolutionized cancer treatment in the past decades. However, its efficacy is still limited to …