Method As examples of the new approaches that have emerged, here we introduce the
Hierarchical Taxonomy of Psychopathology (HiTOP), the Research Domain Criteria (RDoC) …

Many studies show the importance of biological sex for the onset, progression, and
response to treatment in brain disorders. In line with these reports, health agencies have …

Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT2A
receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5 …

Whilst reward pathologies are major and common in stress-related neuropsychiatric
disorders, their neurobiology and treatment are poorly understood. Imaging studies in …

Depression shows a metabolomic signature overlapping with that of cardiometabolic
conditions. Whether this signature is linked to specific depression profiles remains …

Mental disorder (earlier entitled “illness” or “disease”) is ascribed to deviations from normal
thoughts, reasoning, feelings, attitudes, and actions that are considered socially or …

Introduction The ability to perform optimally under pressure is critical across many
occupations, including the military, first responders, and competitive sport. Despite …

Importance Psychomotor slowing is a frequent symptom of psychosis, impairing gross and
fine motor behavior. It is associated with poor outcomes and functioning, and no treatment is …

Stress can have severe psychological and physiological consequences. Thus, inappropriate
regulation of the stress response is linked to the etiology of mood and anxiety disorders. The …

Precision medicine is promoted as the health care paradigm of the 21st century, 1 destined
to eventually replace evidence-based medicine (EBM) as the dominant paradigm of medical …