Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …

Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …

Myofibroblasts are non-muscle contractile cells that play a key physiologically role in organs
such as the stem villi of the human placenta during physiological pregnancy. They are able …

Fibrosis is a chronic and progressive process characterized by an excessive accumulation
of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue …

The fibrotic diseases encompass a wide spectrum of entities including such multisystemic
diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft …

Transforming growth factor beta (TGFβ) induced differentiation of human lung fibroblasts to
myofibroblasts is a key event in the pathogenesis of pulmonary fibrosis. Although the typical …

Systemic sclerosis (SSc) is a complex and incompletely understood disease associated with
fibrosis in multiple organs. Recent findings identify transforming growth factor-ß (TGF-ß), Wnt …

The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is
expressed in multiple cell types in addition to adipocytes. Upon its activation by natural …

Epithelial-mesenchymal transition (EMT) was shown to confer tumor cells with abilities
essential for metastasis, including migratory phenotype, invasiveness, resistance to …