Galangin Nanoparticles Protect Acetaminophen‐Induced Liver Injury: A Biochemical and Histopathological Approach
A Mohammadi, S Kazemi… - Evidence‐Based …, 2022 - Wiley Online Library
One of the main causes of acute liver failure is overdose with acetaminophen. Excessive
consumption of acetaminophen leads to the production of NAPQI (N‐acetyl‐p …
consumption of acetaminophen leads to the production of NAPQI (N‐acetyl‐p …
A physiology-based model of human bile acid metabolism for predicting bile acid tissue levels after drug administration in healthy subjects and BRIC type 2 patients
V Baier, H Cordes, C Thiel, JV Castell… - Frontiers in …, 2019 - frontiersin.org
Drug-induced liver injury (DILI) is a matter of concern in the course of drug development and
patient safety, often leading to discontinuation of drug-development programs or early …
patient safety, often leading to discontinuation of drug-development programs or early …
Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations
C Thiel, I Smit, V Baier, H Cordes, B Fabry… - NPJ systems biology …, 2018 - nature.com
A quantitative analysis of dose–response relationships is essential in preclinical and clinical
drug development in order to optimize drug efficacy and safety, respectively. However, there …
drug development in order to optimize drug efficacy and safety, respectively. However, there …
A model‐based workflow to benchmark the clinical cholestasis risk of drugs
V Baier, O Clayton, R Nudischer… - Clinical …, 2021 - Wiley Online Library
We present a generic workflow combining physiology‐based computational modeling and in
vitro data to assess the clinical cholestatic risk of different drugs systematically. Changes in …
vitro data to assess the clinical cholestatic risk of different drugs systematically. Changes in …
Quantitative systems pharmacology of interferon alpha administration: a multi-scale approach
P Kalra, J Brandl, T Gaub, C Niederalt, J Lippert… - PLoS …, 2019 - journals.plos.org
The therapeutic effect of a drug is governed by its pharmacokinetics which determine the
downstream pharmacodynamic response within the cellular network. A complete …
downstream pharmacodynamic response within the cellular network. A complete …
孕烷X 受体: 肝脏疾病的潜在药物靶标
辛瑜， 杨暄， 奚涛， 熊晶 - 药学进展, 2018 - pps.cpu.edu.cn
孕烷X 受体(PXR) 属于配体依赖性调控靶基因的核受体亚家族, 激活后可调控多种药物代谢酶和
转运体的表达, 影响临床药物的疗效和耐药性. PXR 通过调控肝脏中脂质和糖类物质的代谢 …
转运体的表达, 影响临床药物的疗效和耐药性. PXR 通过调控肝脏中脂质和糖类物质的代谢 …
Tools and data towards supporting quantitative systems pharmacology of the eye–an overview
L Kuepfer, G Fuellen, T Stahnke - 2022 - preprints.org
Good eyesight belongs to the most-valued attributes of health, and diseases of the eye are a
significant health care burden. Case numbers are expected to further increase in the next …
significant health care burden. Case numbers are expected to further increase in the next …
[图书][B] Physiologically-based pharmacokinetic modelling for the prediction of adverse drug reactions
Nebenwirkungen von Medikamenten bedrohen nicht nur Patienten und deren Gesundheit,
sondern stellen auch die Arzneimittelentwicklung sowie den klinischen Alltag vor …
sondern stellen auch die Arzneimittelentwicklung sowie den klinischen Alltag vor …
A physiology-based model of bile acid metabolism shows altered tissue concentrations after drug administration and in specific genotype subgroups
Drug-induced liver injuries (DILI) are an important issue in drug development and patient
safety and often lead to termination of drug-development programs or late withdrawals of …
safety and often lead to termination of drug-development programs or late withdrawals of …
[PDF][PDF] 孕烷X 受体: 肝脏疾病的潜在药物靶标
辛瑜， 杨暄， 奚涛， 熊晶 - PROGRESS IN PHARMACEUTICAL …, 2018 - pps.cpu.edu.cn
孕烷X 受体(PXR) 属于配体依赖性调控靶基因的核受体亚家族, 激活后可调控多种药物代谢酶和
转运体的表达, 影响临床药物的疗效和耐药性. PXR 通过调控肝脏中脂质和糖类物质的代谢 …
转运体的表达, 影响临床药物的疗效和耐药性. PXR 通过调控肝脏中脂质和糖类物质的代谢 …