A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was
recently implicated in various autoimmune disorders. Tregs are responsible for the …

As a ligand-dependent transcription factor, retinoid-associated orphan receptor γt (RORγt)
that controls T helper (Th) 17 cell differentiation and interleukin (IL)-17 expression plays a …

Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have
used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome …

Retinoic acid–related orphan receptor γt (RORγt) functions as a ligand-dependent
transcription factor that regulates multiple proinflammatory genes and plays a critical role in …

Introduction: The transcription factor retinoic acid-related orphan receptor gamma t (RORγt)
has been identified as the master regulator of TH17 cell differentiation and IL-17/22 …

Psoriasis is a common chronic inflammatory multisystemic disease with a complex
pathogenesis consisting of genetic, immunological, and environmental components. It is …

Cholesterol and its metabolites are bioactive lipids that interact with and regulate the activity
of various proteins and signaling pathways that are implicated in the control of a variety of …

Introduction: The transcription factor RORγ plays a critical role in the expression of pro-
inflammatory cytokine interleukin IL-17 and is therefore an attractive target for the treatment …

Years of researches have demonstrated that the imbalance of Th17 and Tregs contribute to
the thyroid autoimmunity and the severity of autoimmune thyroid disease (AITD). The …

The retinoic acid receptor-related orphan receptor RORγ plays key roles in the development
and differentiation of TH 17 cells, and thus in IL-17 expression, thymocyte development and …