The influenza virus hemagglutinin head evolves faster than the stalk domain

E Kirkpatrick, X Qiu, PC Wilson, J Bahl, F Krammer - Scientific reports, 2018 - nature.com
The limited ability of current influenza virus vaccines to protect from antigenically drifted or
shifted viruses creates a public health problem that has led to the need to develop effective …

The structural variability of the influenza A hemagglutinin receptor-binding site

M Lazniewski, WK Dawson… - Briefings in …, 2018 - academic.oup.com
Hemagglutinin (HA) is a transmembrane protein of the influenza A virus and a key
component in its life cycle. The protein allows the virus to enter a host cell by recognizing …

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses

RA Neher, T Bedford, RS Daniels… - Proceedings of the …, 2016 - National Acad Sciences
Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade
immunity and reinfect previously infected individuals. Antigenic properties are largely …

Genome-wide evolutionary dynamics of influenza B viruses on a global scale

P Langat, J Raghwani, G Dudas, TA Bowden… - PLoS …, 2017 - journals.plos.org
The global-scale epidemiology and genome-wide evolutionary dynamics of influenza B
remain poorly understood compared with influenza A viruses. We compiled a spatio …

Sequence‐free phylogenetics with mass spectrometry

KM Downard - Mass Spectrometry Reviews, 2022 - Wiley Online Library
An alternative, more rapid, sequence‐free approach to build phylogenetic trees has been
conceived and implemented. Molecular phylogenetics has continued to mostly focus on …

Broadly cross-reactive, nonneutralizing antibodies against influenza B virus hemagglutinin demonstrate effector function-dependent protection against lethal viral …

G Asthagiri Arunkumar, A Ioannou, TJ Wohlbold… - Journal of …, 2019 - Am Soc Microbiol
Protection from influenza virus infection is canonically associated with antibodies that
neutralize the virus by blocking the interaction between the viral hemagglutinin and host cell …

Chimeric hemagglutinin constructs induce broad protection against influenza B virus challenge in the mouse model

ME Ermler, E Kirkpatrick, W Sun, R Hai… - Journal of …, 2017 - Am Soc Microbiol
Seasonal influenza virus epidemics represent a significant public health burden.
Approximately 25% of all influenza virus infections are caused by type B viruses, and these …

Substitutions near the HA receptor binding site explain the origin and major antigenic change of the B/Victoria and B/Yamagata lineages

ME Rosu, P Lexmond, TM Bestebroer… - Proceedings of the …, 2022 - National Acad Sciences
Influenza B virus primarily infects humans, causing seasonal epidemics globally. Two
antigenic variants—Victoria-like and Yamagata-like—were detected in the 1980s, of which …

[HTML][HTML] IgA responses following recurrent influenza virus vaccination

RB Abreu, EF Clutter, S Attari, GA Sautto… - Frontiers in …, 2020 - frontiersin.org
Influenza is a highly contagious viral respiratory disease that affects millions of people
worldwide each year. Annual vaccination is recommended by the World Health Organization …

Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

Y Liu, HX Tan, M Koutsakos, S Jegaskanda… - Nature …, 2019 - nature.com
Influenza B viruses (IBV) drive a significant proportion of influenza-related hospitalisations
yet are understudied compared to influenza A. Current vaccines target the head of the viral …