Methotrexate and its mechanisms of action in inflammatory arthritis

BN Cronstein, TM Aune - Nature Reviews Rheumatology, 2020 - nature.com
Despite the introduction of numerous biologic agents for the treatment of rheumatoid arthritis
(RA) and other forms of inflammatory arthritis, low-dose methotrexate therapy remains the …

Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review

J Karami, S Aslani, A Jamshidi, M Garshasbi… - Gene, 2019 - Elsevier
Three important factors, including genetics, environment factors and autoimmunity play a
role in the pathogenesis of rheumatoid arthritis (RA). The heritability of RA has been …

Genetics of rheumatoid arthritis—a comprehensive review

J Kurkó, T Besenyei, J Laki, TT Glant, K Mikecz… - Clinical reviews in …, 2013 - Springer
The “Bermuda triangle” of genetics, environment and autoimmunity is involved in the
pathogenesis of rheumatoid arthritis (RA). Various aspects of genetic contribution to the …

Systemic inflammatory response and atherosclerosis: the paradigm of chronic inflammatory rheumatic diseases

A Arida, AD Protogerou, GD Kitas… - International journal of …, 2018 - mdpi.com
Patients with Chronic Inflammatory Rheumatic diseases (CIRD) are at increased risk of
cardiovascular disease (CVD), ascribed not only to classical risk factors, but also to the …

[HTML][HTML] Clinical and pathophysiologic relevance of autoantibodies in rheumatoid arthritis

SB Rocha, DC Baldo, LEC Andrade - Advances in Rheumatology, 2019 - SciELO Brasil
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disease affecting 0.5 to 1% of
adults worldwide and frequently leads to joint destruction and disability. Early diagnosis and …

Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?

KH Costenbader, S Gay, ME Alarcón-Riquelme… - Autoimmunity …, 2012 - Elsevier
Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple
sclerosis and inflammatory bowel disease, have complex pathogeneses and likely …

A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus

RC Ho, C Thiaghu, H Ong, Y Lu, CS Ho, WW Tam… - Autoimmunity …, 2016 - Elsevier
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most devastating
presentations of SLE and comprises of psychiatric, central and peripheral neurological signs …

Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid

M Karami Fath, J Azami, N Jaafari… - Cellular & Molecular …, 2022 - Springer
Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising
heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered …

Endothelial dysfunction in rheumatic autoimmune diseases

G Murdaca, BM Colombo, P Cagnati, R Gulli, F Spanò… - Atherosclerosis, 2012 - Elsevier
Rheumatic autoimmune diseases have been associated with accelerated atherosclerosis
and various types of vasculopathies. Atherosclerosis is an inflammatory condition which …

[HTML][HTML] Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women

Y Hu, KH Costenbader, X Gao, M Al-Daabil… - The American journal of …, 2014 - Elsevier
Background: Sugar-sweetened soda consumption is consistently associated with an
increased risk of several chronic inflammatory diseases such as type 2 diabetes and …