Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

RNA-binding proteins contribute to small RNA loading in plant extracellular vesicles

B He, Q Cai, L Qiao, CY Huang, S Wang, W Miao, T Ha… - Nature plants, 2021 - nature.com
Plants use extracellular vesicles (EVs) to transport small RNAs (sRNAs) into their fungal
pathogens and silence fungal virulence-related genes through a phenomenon called 'cross …

Routes and mechanisms of extracellular vesicle uptake

LA Mulcahy, RC Pink, DRF Carter - Journal of extracellular …, 2014 - Taylor & Francis
Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Regulation of immune responses by extracellular vesicles

PD Robbins, AE Morelli - Nature Reviews Immunology, 2014 - nature.com
Extracellular vesicles, including exosomes, are small membrane vesicles derived from
multivesicular bodies or from the plasma membrane. Most, if not all, cell types release …

Physiologic events of embryo implantation and decidualization in human and non-human primates

MA Ochoa-Bernal, AT Fazleabas - International journal of molecular …, 2020 - mdpi.com
Reproduction is a fundamental process for the preservation of the human species. This
process requires a sequence of orchestrated events that are necessary for a successful …

microRNA therapeutics in cancer—an emerging concept

MY Shah, A Ferrajoli, AK Sood, G Lopez-Berestein… - …, 2016 - thelancet.com
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …

Tetraspanins, more than markers of extracellular vesicles in reproduction

J Jankovičová, P Sečová, K Michalková… - International Journal of …, 2020 - mdpi.com
The participation of extracellular vesicles in many cellular processes, including reproduction,
is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles …

Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus

ES Green, PC Arck - Seminars in immunopathology, 2020 - Springer
Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

Classification, functions, and clinical relevance of extracellular vesicles

E Van der Pol, AN Böing, P Harrison, A Sturk… - Pharmacological …, 2012 - Elsevier
Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into
their environment. Why do cells release vesicles? Initial studies showed that eukaryotic …