Elucidating the biological and biochemical roles of proteins, and subsequently determining
their interacting partners, can be difficult and time consuming using in vitro and/or in vivo …

Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …

Understanding the mechanisms of protein function is indispensable for many biological
applications, such as protein engineering and drug design. However, experimental …

Functional annotation of protein sequence with high accuracy has become one of the most
important issues in modern biomedical studies, and computational approaches of …

Automated function prediction (AFP) of proteins is of great significance in biology. AFP can
be regarded as a problem of the large-scale multi-label classification where a protein can be …

Knowledge of protein function is important for biological, medical and therapeutic studies,
but many proteins are still unknown in function. There is a need for more improved functional …

Abstract Domains are functional and structural units of proteins that govern various
biological functions performed by the proteins. Therefore, the characterization of domains in …

In this study, we developed a method named GoFDR for predicting Gene Ontology (GO)-
based protein functions. The input for GoFDR is simply a query sequence-based multiple …

The use of pharmaceuticals to treat Major Depressive Disorder (MDD) has several
drawbacks, including severe side effects. Natural compounds with great efficacy and few …

Understanding the functions of proteins is crucial to understand biological processes on a
molecular level. Many more protein sequences are available than can be investigated …