Targeted protein degradation (TPD) represents a promising therapeutic approach,
encompassing several innovative strategies, including but not limited to proteolysis targeting …

Interleukin-1 receptor-associated kinase 4 (IRAK4) is involved in various inflammation-
related diseases. Both the kinase and scaffolding functions of IRAK4 initiate pro …

Modulating the chemical composition of cereblon (CRBN) binders is a critical step in the
optimization process of protein degraders that seek to hijack the function of this E3 ligase …

PROTACs are an emerging therapeutic approach towards targeted protein degradation.
This article examines the leading examples of this modality that are in clinical development …

Herein we report the discovery of an azabicyclo [2.1. 1] hexane piperazinium
methanesulfonate salt from an unexpected rearrangement reaction in the preparation of …

Targeted protein degradation (TPD) has emerged as a significant therapeutic approach for a
variety of diseases, including cancer. Advances in TPD techniques, such as molecular glue …

PROTACs usually occupy physicochemical space outside the one defined by classical drug-
like molecules, which often presents considerable challenges in their optimization and …

IRAK4 inhibitors have been sought for the treatment of a host of diseases, however, recent
evidence suggests a protein degradation approach might have advantages over an …

In recent years, targeted protein degradation (TPD) has emerged as a powerful therapeutic
modality utilizing both heterobifunctional ligand-directed degraders (LDDs) and molecular …