Insights into Machine Learning-based approaches for Virtual Screening in Drug Discovery: Existing strategies and streamlining through FP-CADD
Background: Machine learning is an active area of research in computer science by the
availability of big data collection of all sorts prompting interest in the development of novel …
availability of big data collection of all sorts prompting interest in the development of novel …
A treatise to computational approaches towards prediction of membrane protein and its subtypes
Membrane proteins are vital mediating molecules responsible for the interaction of a cell
with its surroundings. These proteins are involved in different functionalities such as ferrying …
with its surroundings. These proteins are involved in different functionalities such as ferrying …
SPalmitoylC-PseAAC: A sequence-based model developed via Chou's 5-steps rule and general PseAAC for identifying S-palmitoylation sites in proteins
S-Palmitoylation is a uniquely reversible and biologically important post-translational
modification as it plays an essential role in a variety of cellular processes including signal …
modification as it plays an essential role in a variety of cellular processes including signal …
SPrenylC-PseAAC: A sequence-based model developed via Chou's 5-steps rule and general PseAAC for identifying S-prenylation sites in proteins
The protein prenylation (or S-prenylation) is one of the most essential modifications,
required for the association of membrane of a plethora of signalling proteins with the key …
required for the association of membrane of a plethora of signalling proteins with the key …
iPhosT-PseAAC: Identify phosphothreonine sites by incorporating sequence statistical moments into PseAAC
Among all the post-translational modifications (PTMs) of proteins, Phosphorylation is known
to be the most important and highly occurring PTM in eukaryotes and prokaryotes. It has an …
to be the most important and highly occurring PTM in eukaryotes and prokaryotes. It has an …
Identification of 4-carboxyglutamate residue sites based on position based statistical feature and multiple classification
AA Shah, YD Khan - Scientific Reports, 2020 - nature.com
Glutamic acid is an alpha-amino acid used by all living beings in protein biosynthesis. One
of the important glutamic acid modifications is post-translationally modified 4 …
of the important glutamic acid modifications is post-translationally modified 4 …
iSUMOK-PseAAC: prediction of lysine sumoylation sites using statistical moments and Chou's PseAAC
Sumoylation is the post-translational modification that is involved in the adaption of the cells
and the functional properties of a large number of proteins. Sumoylation has key importance …
and the functional properties of a large number of proteins. Sumoylation has key importance …
Optimization of serine phosphorylation prediction in proteins by comparing human engineered features and deep representations
Deep representations can be used to replace human-engineered representations, as such
features are constrained by certain limitations. For the prediction of protein post-translation …
features are constrained by certain limitations. For the prediction of protein post-translation …
iTSP-PseAAC: identifying tumor suppressor proteins by using fully connected neural network and PseAAC
Background: The uncontrolled growth due to accumulation of genetic and epigenetic
changes as a result of loss or reduction in the normal function of Tumor Suppressor Genes …
changes as a result of loss or reduction in the normal function of Tumor Suppressor Genes …
iMem-2LSAAC: a two-level model for discrimination of membrane proteins and their types by extending the notion of SAAC into Chou's pseudo amino acid …
Membrane proteins execute significant roles in cellular processes of living organisms,
ranging from cell signaling to cell adhesion. As a major part of a cell, the identification of …
ranging from cell signaling to cell adhesion. As a major part of a cell, the identification of …