Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

Disease modeling and target identification are the most crucial initial steps in drug
discovery, and influence the probability of success at every step of drug development …

More information about a person's genetic makeup, drug response, multi-omics response,
and genomic response is now available leading to a gradual shift towards personalized …

Ethnopharmacology, through the description of the beneficial effects of plants, has provided
an early framework for the therapeutic use of natural compounds. Natural products, either in …

The explosive growth in medical devices, imaging and diagnostics, computing, and
communication and information technologies in drug development and healthcare has …

Highlights•This review re-explores the comparison between phenotypic and target-based
drug discovery and outlines how machine learning (ML) can assist the former at the forefront …

Recently, the need to develop a robust three-dimensional (3D) cell culture system that
serves as a valuable in vitro tumor model has been emphasized. This system should closely …

Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …

Recent advances in deep learning enabled the development of AI systems that outperform
humans in many tasks and have started to empower scientists and physicians with new …

Developing new therapeutic strategies to target specific molecular pathways has become a
primary focus in modern drug discovery science. Fibroblast growth factor receptor 2 (FGFR2) …