Uncontrolled hypertension persists as an important health issue despite the availability of
many medications and nondrug therapies that lower blood pressure. Increasingly …

BACKGROUND: Renal denervation (RDN) has demonstrated clinically relevant reductions
in blood pressure (BP) among individuals with uncontrolled hypertension despite lifestyle …

Background Ultrasound and radiofrequency renal denervation (RDN) have been shown to
safely lower blood pressure (BP) in hypertension. Aims The TARGET BP OFF-MED trial …

Arterial hypertension is the most prevalent global modifiable risk factor for cardiovascular
morbidity and mortality. Despite the availability of numerous pharmacologic treatments …

Chiral drugs are of great significance in drug development and life science because one
pair of enantiomers has a different combination mode with target biological active sites …

Background: Primary results of this prospective, open-label, multicenter trial suggested that
alcohol-mediated renal denervation with perivascular injection of dehydrated alcohol using …

Hypertension remains the leading cause of death worldwide. Despite advances in drug-
based treatment, many patients do not achieve target blood pressure. In recent years, there …

Renal artery denervation has re-emerged as a potential therapeutic option for patients with
hypertension, especially those resistant to conventional pharmacotherapy. This …

Background: This meta-analysis was designed to evaluate the antihypertensive efficacy of
intravascular renal denervation (RDN) in patients with essential hypertension, especially to …

Motivated by the persistence of uncontrolled blood pressure and its public health impact, the
development and evaluation of device-based therapies for hypertension has advanced at an …