MRNA therapy for Fabry disease

BC Guild, F DeRosa, M Heartlein - US Patent 9,308,281, 2016 - Google Patents
US9308281B2 - MRNA therapy for Fabry disease - Google Patents US9308281B2 - MRNA
therapy for Fabry disease - Google Patents MRNA therapy for Fabry disease Download PDF …

MRNA therapy for phenylketonuria

F DeRosa, M Heartlein, A Dias - US Patent 9,522,176, 2016 - Google Patents
3,096.560 A 7, 1963 Liebig(PAH) at an effective dose and an administration interval
3,535,289 A 10, 1970 Yoshihara et al. such that at least one symptom or feature of PKU is …

Pulmonary delivery of mRNA

BC Guild, F DeRosa, M Heartlein - US Patent 9,597,413, 2017 - Google Patents
US9597413B2 - Pulmonary delivery of mRNA - Google Patents US9597413B2 - Pulmonary
delivery of mRNA - Google Patents Pulmonary delivery of mRNA Download PDF Info Publication …

Cftr mrna compositions and related methods and uses

M Heartlein, BC Guild, F DeRosa, C Rudolph… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
50513499&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

MRNA therapy for argininosuccinate synthetase deficiency

M Heartlein, F DeRosa, L Smith - US Patent 11,224,642, 2022 - Google Patents
The present invention provides, among other things, meth ods of treating Argininosuccinate
Synthetase Deficiency (ASD), including administering to a subject in need of treatment a …

Lipid nanoparticle compositions and methods for MRNA delivery

BC Guild, F DeRosa, M Heartlein - US Patent 10,238,754, 2019 - Google Patents
US10238754B2 - Lipid nanoparticle compositions and methods for MRNA delivery - Google
Patents US10238754B2 - Lipid nanoparticle compositions and methods for MRNA delivery …

Methods for purification of messenger RNA

F DeRosa, A Dias, S Karve, M Heartlein - US Patent 9,850,269, 2017 - Google Patents
The present invention provides, among other things, methods of purifying messenger RNA
(mRNA) including the steps of (a) precipitating mRNA from an impure preparation;(b) …

Methods for purification of messenger RNA

M Heartlein, F DeRosa, A Dias, S Karve - US Patent 9,957,499, 2018 - Google Patents
The present invention provides, among other things, methods of purifying messenger RNA
(mRNA) including the steps of subjecting an impure preparation comprising in vitro …

Lipid nanoparticle compositions and methods for mRNA delivery

BC Guild, F DeRosa, M Heartlein - US Patent 10,413,618, 2019 - Google Patents
US10413618B2 - Lipid nanoparticle compositions and methods for mRNA delivery - Google
Patents US10413618B2 - Lipid nanoparticle compositions and methods for mRNA delivery …

Lipid nanoparticle compositions and methods for mRNA delivery

BC Guild, F DeRosa, M Heartlein - US Patent 10,350,303, 2019 - Google Patents
US10350303B1 - Lipid nanoparticle compositions and methods for mRNA delivery - Google
Patents US10350303B1 - Lipid nanoparticle compositions and methods for mRNA delivery …