The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Oxygen (O2) quantification is essential for assessing cell metabolism, and its consumption in
cell culture is an important indicator of cell viability. Recent advances in microfluidics have …

The establishment of tumor microenvironment using biomimetic in vitro models that
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …

Hydrogel-based three-dimensional (3D) cell culture systems mimic the salient elements of
extracellular matrices and promote native cell function. However, high-resolution 3D cell …

Three-dimensional bioprinting can fabricate precisely controlled 3D tissue constructs. This
process uses bioinks—specially tailored materials that support the survival of incorporated …

Breast cancer (BC) metastasis is an enormous challenge targeting BC therapy. The
extracellular matrix (ECM), the principal component of the BC metastasis niche, is the pivotal …

Rare earth lanthanum oxide nanoparticle reinforced collagen biomatrix that elicited the
endothelial cell activation to promote angiogenesis for biomaterial integration was …

Gold nanoparticles have emerged as a prominent tool in nanomedicine, particularly for
applications in cancer diagnostic and treatment. One of the challenges for the successful …

Nanomedicines have long been expected to significantly enhance cancer treatment.
However, their clinical translation is still very limited despite the world's great efforts during …

The traditional 2d culture has been proved inferior to reproduce the subtle interaction
between cell-to-cell and cell-to-extracellular matrix (ECM) in tumor microenvironment (TME) …