Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Technological advances have paved the way for accelerated genomic discovery and are
bringing precision medicine clearly into view. Epilepsy research in particular is well suited to …

There is high variability in the response to antiepileptic treatment across people with
epilepsy. Genetic factors significantly contribute to such variability. Recent advances in the …

Mitophagy is one of the processes that cells use to maintain overall health. An E3 ligase,
parkin, ubiquitinates mitochondrial proteins prior to their degradation by autophagasomes …

Defective centrosome duplication is implicated in microcephaly and primordial dwarfism as
well as various ciliopathies and cancers. Yet, how the centrosome biogenesis is regulated …

Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) belonging to the
USP subfamily, which was found localized in the mitochondrial outer membrane and …

Mutations in more than a hundred genes have been reported to cause X-linked recessive
intellectual disability (ID) mainly in males. In contrast, the number of identified X-linked …

Most proteins undergo posttranslational modification such as acetylation, methylation,
phosphorylation, biotinylation, and ubiquitination to regulate various cellular processes …

Epilepsy and autistic spectrum disorder frequently coexist in the same individual.
Electroencephalogram (EEG) epileptiform activity is also present at a substantially higher …

Gemcitabine is the cornerstone of pancreatic cancer treatment. Although effective in most
patients, development of tumor resistance to gemcitabine can critically limit its efficacy. The …