The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

TorsinA is a membrane‐associated enzyme in the endoplasmic reticulum (ER) lumen that is
mutated in DYT1 dystonia. How it remains in the ER has been unclear. We report that a …

The morphology and curvature of biological bilayers are determined by the packing shapes
and interactions of their participant molecules. Bacteria, except photosynthetic groups …

A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction
of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein …

Sorting of membrane proteins into intracellular organelles is crucial for cell function. Viruses
exploit intracellular transport and retention systems to concentrate envelope proteins at the …

Abstract Cyclooxygenases (COX-1 and COX-2) oxygenate arachidonic acid (AA) to
generate prostaglandins. The enzymes associate with one leaflet of the membrane bilayer …

To understand the structural features that dictate the selectivity of the two isoforms of the
prostaglandin H2 synthase (PGHS/COX), the three‐dimensional (3D) structure of COX …

Abstract Prostaglandin H 2 synthase (PGHS; EC 1.14. 99.1), a bi-functional heme enzyme
that contains cyclooxygenase and peroxidase activities, plays a central role in the …

Cyclooxygenases carry out the committed step in prostaglandin synthesis and are the target
of NSAIDs, the most widely used class of drugs in alleviating pain, fever, and inflammation …

The ductus arteriosus (DA) is a muscular artery which helps to define the fetal pattern of the
circulatory system. After birth, the DA undergoes muscular constriction and remodeling …