Mycobacterium smegmatis: the vanguard of mycobacterial research

IL Sparks, KM Derbyshire, WR Jacobs Jr… - Journal of …, 2023 - Am Soc Microbiol
The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Protein synthesis in Mycobacterium tuberculosis as a potential target for therapeutic interventions

N Kumar, S Sharma, PS Kaushal - Molecular Aspects of Medicine, 2021 - Elsevier
Mycobacterium tuberculosis (Mtb) causes one of humankind's deadliest diseases,
tuberculosis. Mtb protein synthesis machinery possesses several unique species-specific …

Premature termination of transcription is shaped by Rho and translated uORFS in Mycobacterium tuberculosis

A D'Halluin, P Polgar, T Kipkorir, Z Patel, T Cortes… - Iscience, 2023 - cell.com
Little is known about the decisions behind transcription elongation versus termination in the
human pathogen Mycobacterium tuberculosis (M. TB). By applying Term-seq to M. TB we …

Pervasive translation in Mycobacterium tuberculosis

C Smith, JG Canestrari, AJ Wang, MM Champion… - Elife, 2022 - elifesciences.org
Most bacterial ORFs are identified by automated prediction algorithms. However, these
algorithms often fail to identify ORFs lacking canonical features such as a length of> 50 …

Diverse intrinsic properties shape transcript stability and stabilization in Mycolicibacterium smegmatis

H Sun, DA Vargas-Blanco, Y Zhou… - NAR Genomics and …, 2024 - academic.oup.com
Mycobacteria regulate transcript degradation to facilitate adaptation to environmental stress.
However, the mechanisms underlying this regulation are unknown. Here we sought to gain …

Integrated sequence and -omic features reveal novel small proteome of Mycobacterium tuberculosis

PR Sinha, R Balasubramanian, SR Hegde - Frontiers in Microbiology, 2024 - frontiersin.org
Bioinformatic studies on small proteins are under-represented due to difficulties in
annotation posed by their small size. However, recent discoveries emphasize the functional …

Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex

J Stiens, KB Arnvig, SL Kendall… - Molecular …, 2022 - Wiley Online Library
A definitive transcriptome atlas for the non‐coding expressed elements of the members of
the Mycobacterium tuberculosis complex (MTBC) does not exist. Incomplete lists of non …

In vitro activity of new combinations of β-lactam and β-lactamase inhibitors against the Mycobacterium tuberculosis complex

E Economou Lundeberg, V Andersson… - Microbiology …, 2023 - Am Soc Microbiol
As meropenem-clavulanic acid is recommended for the treatment of drug-resistant
tuberculosis, the repurposing of new carbapenem combinations may provide new treatment …

Translation of a Leaderless Reporter Is Robust During Exponential Growth and Well Sustained During Stress Conditions in Mycobacterium tuberculosis

AD Grabowska, N Andreu, T Cortes - Frontiers in microbiology, 2021 - frontiersin.org
Mycobacterium tuberculosis expresses a large number of leaderless mRNA transcripts;
these lack the 5′ leader region, which usually contains the Shine–Dalgarno sequence …

Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome

X Ju, S Li, R Froom, L Wang, M Lilic, M Delbeau… - Nature, 2024 - nature.com
Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that causes tuberculosis (TB), an
infectious disease that is responsible for major health and economic costs worldwide. Mtb …