Schwann cells within the peripheral nervous system possess a remarkable regenerative
potential. Current research shows that peripheral nerve‐associated Schwann cells possess …

The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has
become widely known because of its functional relevance for stem cells. In the developing …

Peripheral nerves are organ-like structures containing diverse cell types to optimize function.
This interactive assembly includes mostly axon-associated Schwann cells, but also …

Axon degeneration is a hallmark of many neurodegenerative disorders. The current
assumption is that the decision of injured axons to degenerate is cell-autonomously …

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for
regeneration. Normally providing strong regenerative support, these cells fail in aging …

Whereas microglia are recognized as fundamental players in central nervous system (CNS)
development and function, much less is known about macrophages of the peripheral …

Notch signaling is central to vertebrate development, and analysis of Notch has provided
important insights into pathogenetic mechanisms in the CNS and many other tissues …

Mitochondrial dysfunction is a common cause of peripheral neuropathy. Much effort has
been devoted to examining the role played by neuronal/axonal mitochondria, but how …

Peripheral nerves and Schwann cells have to sustain constant mechanical constraints,
caused by developmental growth as well as stretches associated with movements of the …

Myelination is essential for nervous system function. Schwann cells interact with neurons
and the basal lamina to myelinate axons using known receptors, signals and transcription …