Microwave assisted reactions of azaheterocycles formedicinal chemistry applications
D Amariucai-Mantu, V Mangalagiu, R Danac… - Molecules, 2020 - mdpi.com
Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles
chemistry during the last decades. Five and six membered ring azaheterocycles are …
chemistry during the last decades. Five and six membered ring azaheterocycles are …
Phthalimide as a versatile pharmacophore scaffold: Unlocking its diverse biological activities
GFS Fernandes, JR Lopes… - Drug Development …, 2023 - Wiley Online Library
Phthalimide, a pharmacophore exhibiting diverse biological activities, holds a prominent
position in medicinal chemistry. In recent decades, numerous derivatives of phthalimide …
position in medicinal chemistry. In recent decades, numerous derivatives of phthalimide …
Antiviral evaluation of hydroxyethylamine analogs: Inhibitors of SARS-CoV-2 main protease (3CLpro), a virtual screening and simulation approach
The continued toll of COVID-19 has halted the smooth functioning of civilization on a global
scale. With a limited understanding of all the essential components of viral machinery and …
scale. With a limited understanding of all the essential components of viral machinery and …
Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria
V Singh, RS Hada, R Jain, M Vashistha… - European Journal of …, 2022 - Elsevier
Constant emergence of drug-resistant Plasmodium falciparum warrants urgent need for
effective and inexpensive drugs. Herein, phthalimide (Pht) analogs possessing the bioactive …
effective and inexpensive drugs. Herein, phthalimide (Pht) analogs possessing the bioactive …
Expanding the scope of novel 1, 2, 3-triazole derivatives as new antiparasitic drug candidates
R Carlucci, G Di Gresia, MG Mediavilla… - RSC Medicinal …, 2023 - pubs.rsc.org
We have previously shown that prenyl and aliphatic triazoles are interesting motifs to
prepare new chemical entities for antiparasitic and antituberculosis drug development. In …
prepare new chemical entities for antiparasitic and antituberculosis drug development. In …
Phthalimide analogs for antimalarial drug discovery
Malaria remains one of the world's most life-threatening diseases and, thus, it is a major
public health concern all around the world. The disease can become devastating if not …
public health concern all around the world. The disease can become devastating if not …
The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel
Malaria elimination urgently needs novel antimalarial therapies that transcend resistance,
toxicity, and high costs. Our multicentric international collaborative team focuses on …
toxicity, and high costs. Our multicentric international collaborative team focuses on …
Fast-acting small molecules targeting malarial aspartyl proteases, plasmepsins, inhibit malaria infection at multiple life stages
The eradication of malaria remains challenging due to the complex life cycle of Plasmodium
and the rapid emergence of drug-resistant forms of Plasmodium falciparum and Plasmodium …
and the rapid emergence of drug-resistant forms of Plasmodium falciparum and Plasmodium …
Phenotypic screening reveals a highly selective phthalimide-based compound with antileishmanial activity
Pharmacophores such as hydroxyethylamine (HEA) and phthalimide (PHT) have been
identified as potential synthons for the development of compounds against various parasitic …
identified as potential synthons for the development of compounds against various parasitic …
Synthesis and bioactivity of phthalimide analogs as potential drugs to treat schistosomiasis, a neglected disease of poverty
The neglected tropical disease, schistosomiasis, is caused by trematode blood flukes of the
Schistosoma genus and infects approximately 200 million people worldwide. With just one …
Schistosoma genus and infects approximately 200 million people worldwide. With just one …