Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with
epilepsy. The drugs have the remarkable ability to protect against seizures while permitting …

Ion channels serve many functions apart from electrical signal transduction: chemical
signalling (Ca2+ as a second messenger), transepithelial transport, regulation of …

CACNA1A loss-of-function mutations classically present as episodic ataxia type 2 (EA2),
with brief episodes of ataxia and nystagmus, or with progressive spinocerebellar ataxia …

The present invention relates to a first group of novel genes, here identified as “genomic
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …

A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to
multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and …

The molecular basis of idiopathic generalized epilepsy remains poorly understood. Absence
epilepsy with 3 Hz spike–wave EEG is one of the most common human epilepsies, and is …

Migraine and epilepsy are comorbid episodic disorders that have common pathophysiologic
mechanisms. Migraine attacks, like epileptic seizures, may be triggered by excessive …

All but one of the idiopathic epilepsies with a known molecular basis are channelopathies.
Where the ion channel defects have been identified, however, they generally account for a …

Epilepsy is a common episodic neurological disorder or condition characterized by recurrent
epileptic seizures, and genetics seems to play a key role in its etiology. Early linkage studies …

This review addresses the molecular and cellular mechanisms of diseases caused by
inherited mutations of ion channels in neurones. Among important recent advances is the …