Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Integrin-based adhesion has served as a model for studying the central role of adhesion in
migration. In this article, we outline modes of migration, both integrin-dependent and …

Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von
Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and …