[HTML][HTML] MAGI1, a scaffold protein with tumor suppressive and vascular functions

J Wörthmüller, C Rüegg - Cells, 2021 - mdpi.com
MAGI1 is a cytoplasmic scaffolding protein initially identified as a component of cell-to-cell
contacts stabilizing cadherin-mediated cell–cell adhesion in epithelial and endothelial cells …

[HTML][HTML] A new story of the three magi: Scaffolding proteins and lncRNA suppressors of cancer

L Kotelevets, E Chastre - Cancers, 2021 - mdpi.com
Simple Summary MAGI1, 2, and 3 belong to a subgroup of the MAGUK family of scaffolding
proteins, and are comprised of 6 PDZ domains, 2 WW domains, and 1 GUK domain. MAGIs …

Inactivation of RB1, CDKN2A, and TP53 have distinct effects on genomic stability at side‐by‐side comparison in karyotypically normal cells

N Andersson, KH Saba, L Magnusson… - Genes …, 2023 - Wiley Online Library
Chromosomal instability is a common feature in malignant tumors. Previous studies have
indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A, and TP53 …

[HTML][HTML] The feasibility of detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings

CC Chang, HC Wang, YP Liao… - Journal of …, 2018 - synapse.koreamed.org
Objective We hypothesized that DNA methylation of development-related genes may occur
in endometrial cancer (EC)/ovarian cancer (OC) and may be detected in cervical scrapings …

[HTML][HTML] High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas

P Mei, CE Freitag, L Wei, Y Zhang, AV Parwani… - Diagnostic pathology, 2020 - Springer
Background Immunotherapy has demonstrated encouraging clinical benefits in patients with
advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been …

Magi2/S-Scam Outside Brain

S Nagashima, M Kodaka, H Iwasa… - The journal of …, 2015 - academic.oup.com
Membrane-associated guanylate kinase with an inverted arrangement of protein-protein
interaction domains (MAGI) 2 (also called synaptic scaffolding molecule (S-SCAM), atrophin …

HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer

BL Valle, S Rodriguez-Torres, E Kuhn… - Cancer Prevention …, 2020 - AACR
Molecular alterations that contribute to long-term (LT) and short-term (ST) survival in ovarian
high-grade serous carcinoma (HGSC) may be used as precision medicine biomarkers. DNA …

ERG expression in prostate cancer: biological relevance and clinical implication

H Abou-Ouf, L Zhao, TA Bismar - Journal of cancer research and clinical …, 2016 - Springer
Introduction Screening for increased levels of prostate-specific antigen (PSA) has allowed
early detection of a large majority of prostate cancer (PCa) cases. However, the relative lack …

[HTML][HTML] The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer

J Loaeza-Loaeza, B Illades-Aguiar… - Clinical …, 2022 - Springer
Background High-risk human papillomavirus (HR-HPV) infection is the main cause of
cervical cancer, but additional alterations are necessary for its development. Abnormal DNA …

MAGI2 is an independent predictor of biochemical recurrence in prostate cancer

SN David, SA Arnold Egloff, R Goyal, PE Clark… - The …, 2018 - Wiley Online Library
Background Membrane‐associated guanylate kinase, WW and PDZ domain‐containing
protein 2 (MAGI2) promotes the activity of phosphatase and tensin homolog (PTEN). Recent …