Systematic characterization of antibody–drug conjugate targets in central nervous system tumors
Abstract Background Antibody–drug conjugates (ADCs) enhance the specificity of cytotoxic
drugs by directing them to cells expressing target antigens. Multiple ADCs are FDA …
drugs by directing them to cells expressing target antigens. Multiple ADCs are FDA …
[HTML][HTML] Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome
HN Thirimanne, D Almiron-Bonnin, N Nuechterlein… - Cell genomics, 2024 - cell.com
Meningiomas, although mostly benign, can be recurrent and fatal. World Health
Organization (WHO) grading of the tumor does not always identify high-risk meningioma …
Organization (WHO) grading of the tumor does not always identify high-risk meningioma …
Cost-effectiveness analysis of 68Ga-DOTATATE PET/MRI in radiotherapy planning in patients with intermediate-risk meningioma
J Rodriguez, G Martinez, S Mahase… - American Journal …, 2023 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: While contrast-enhanced MR imaging is the criterion
standard in meningioma diagnosis and treatment response assessment, gallium 68Ga …
standard in meningioma diagnosis and treatment response assessment, gallium 68Ga …
Optimizing the use of Ki-67 proliferative index as a prognostic biomarker in meningiomas using digital analysis
OBJECTIVE Ki-67 immunohistochemistry is widely used as a prognostic marker in
meningiomas, but visual estimations tend to be imprecise. Whether the average Ki-67 over …
meningiomas, but visual estimations tend to be imprecise. Whether the average Ki-67 over …
A novel BRAF:: PTPRN2 fusion in meningioma: a case report
NS Sadagopan, KR Nandoliya… - Acta Neuropathologica …, 2023 - Springer
Gene fusion events have been linked to oncogenesis in many cancers. However, gene
fusions in meningioma are understudied compared to somatic mutations, chromosomal …
fusions in meningioma are understudied compared to somatic mutations, chromosomal …
Functional precision medicine assay for recurrent meningioma: a proof of principle. Illustrative case
WJ Shelton, ES Horta, JS Nix, M Gokden… - Journal of Neurosurgery …, 2024 - thejns.org
BACKGROUND Meningiomas are the most prevalent primary central nervous system
tumors. Although low-grade meningiomas are considered benign tumors, a subset of these …
tumors. Although low-grade meningiomas are considered benign tumors, a subset of these …
Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data
Purpose Accurate classification of cancer subgroups is essential for precision medicine,
tailoring treatments to individual patients based on their cancer subtypes. In recent years …
tailoring treatments to individual patients based on their cancer subtypes. In recent years …