The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

Cilia are hair-like projections found on almost all cells in the human body. Originally
believed to function merely in motility, the function of solitary non-motile (primary) cilia was …

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Chemical synapses between axons and dendrites mediate neuronal intercellular
communication. Here, we describe a synapse between axons and primary cilia: the axo …

Inherited retinal disease is a common cause of visual impairment and represents a highly
heterogeneous group of conditions. Here, we present findings from a cohort of 722 …

The centrosome is the major microtubule-organizing centre of animal cells and through its
influence on the cytoskeleton is involved in cell shape, polarity and motility. It also has a …

Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …

After duplication of the centriole pair during S phase, the centrosome functions as a single
microtubule-organizing center until the onset of mitosis, when the duplicated centrosomes …

Planarians have been a classic model system for the study of regeneration, tissue
homeostasis, and stem cell biology for over a century, but they have not historically been …

Feedback inhibition is a fundamental principle in signal transduction allowing rapid
adaptation to different stimuli. In mammalian cells, the major feedback inhibitor for G-protein …