Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis
chinensis and other Berberis plants. BBR possesses various bioactivities, including …

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Cancer is one of the leading causes of death worldwide, so pursuing effective and safe
therapeutics for cancer is a key research objective nowadays. Doxorubicin (DOX) is one of …

Berberine, as a natural alkaloid compound, is characterized by a diversity of
pharmacological effects. In recent years, many researches focused on the role of berberine …

Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

New insights into the role of berberine against 3-nitropropionic acid-induced striatal
neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling - ScienceDirect …

Neurological disorders are ranked as the leading cause of disability and the second leading
cause of death worldwide, underscoring an urgent necessity to develop novel …

Background The anti-depressant effect of berberine (BBR) has been widely reported.
However, the underlying mechanism remains unclear. The microbiota-gut-brain (MGB) axis …

Chemotherapy-associated neurotoxicity is one of the principal side-effects for doxorubicin
(DOX)-treated cancer patients. Despite its poor-penetration across the blood–brain barrier …

Chemotherapy-related cognitive impairment (CRCI) or “chemo brain” is a devastating
neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here …