Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the
treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R …

Purpose Review and discuss medications efficacious for seizure control, despite primary
indications for other diseases, as treatment options in patients who have failed therapy with …

Aim Depression is the most frequent psychiatric comorbidity in patients with epilepsy.
Fluoxetine is the most widely used selective serotonin reuptake inhibitor (SSRI) in …

Background and purpose Sodium channel blockers (SCBs) have traditionally been utilized
as anti‐seizure medications by primarily targeting the inactivation process. In a drug …

Objective Duplication of the maternal chromosome 15q11. 2‐q13. 1 region causes Dup15q
syndrome, a highly penetrant neurodevelopmental disorder characterized by severe autism …

Rufinamide (RUF) is a structurally unique anti-epileptic drug, but its protective mechanism
against brain injury remains unclear. In the present study, we validated how the RUF …

Background: Epilepsy is a seizure-related disease with different symptoms and types,
depending on the origin and propagation region of the brain. There are several marketed …

Hippocampal slices of mouse brain were used to estimate how selective agonist and
antagonist of opioid receptors alter Low-Mg+ 2 artificial cerebrospinal fluid (LM-ACSF) …

Neuronal hyperexcitability is identified as a critical pathological basis of epileptic seizures.
Cholestane-3β, 5α, 6β-triol (Triol) is a major metabolic oxysterol of cholesterol. Although its …

Rufinamide (RUF) is a structurally unique anti-epileptic drug, used in the treatment of
seizure disorders such as Lennox-Gastaut syndrome. In the present study, we investigated …