The regulation of skeletal muscle blood flow and oxygen delivery to contracting skeletal
muscle is complex and involves the mechanical effects of muscle contraction; local …

During exercise, oxygen and nutrient rich blood must be delivered to the active skeletal
muscle, heart, skin, and brain through the complex and highly regulated integration of …

Endothelin-1 (ET-1), a potent vasoconstrictor secreted by vascular endothelial cells, has
been implicated in the pathophysiology of numerous cardiovascular diseases, yet the direct …

Skeletal muscle is one of the most dynamic metabolic organs as evidenced by increases in
metabolic rate of> 150-fold from rest to maximal contractile activity. Because of limited …

Microvascular function is reduced with age, disease, and inactivity. Exercise is well known to
improve vascular health and has the potential to improve microvascular function in aging …

In young healthy men, passive leg movement (PLM) elicits a robust nitric oxide (NO)-
dependent increase in leg blood flow (LBF), thus providing a novel approach to assess NO …

An exaggerated blood pressure (BP) response to exercise has been linked to
cardiovascular disease, but little is known about the impact of age and sex on this response …

Age-associated structural and functional remodeling of the arterial wall produces a
productive environment for the initiation and progression of hypertension and …

Regulation of skeletal muscle blood flow is a complex process, which involves an integration
of multiple mechanisms and a number of vasoactive compounds. Overall, muscle blood flow …

The American Heart Association recommends no more than 1500 mg of sodium/day as
ideal. Some cohort studies suggest low-sodium intake is associated with increased …