A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

Alternative splicing (AS) in human genes is widely viewed as a mechanism for enhancing
proteomic diversity. AS can also impact gene expression levels without increasing protein …

We assembled the sequences from deep RNA sequencing experiments by the Genotype-
Tissue Expression (GTEx) project, to create a new catalog of human genes and transcripts …

Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species
comparisons have been largely restricted to adult tissues and the functionality of most AS …

Ubiquitous in eukaryotes, circular RNAs (circRNAs) comprise a large class of mostly non-
coding RNAs produced by back-splicing. Although some circRNAs have demonstrated …

The p53 family of proteins evolved from a common ancestor into three separate genes
encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each …

Muscle strength declines with aging and increasing physical activity is the only intervention
known to attenuate this decline. In order to adequately investigate both preventive and …

Stop-codon read-through refers to the phenomenon that a ribosome goes past the stop
codon and continues translating into the otherwise untranslated region (UTR) of a transcript …

Host and environmental factors contribute to variation in human immune responses, yet the
genetic and evolutionary drivers of alternative splicing in response to infection remain …