In general, the various medical systems currently available provide insights into changes in
the tumor genome of patients with tumor sequencing. Most of the tumor DNA sequencing …

Recent advances in sequencing technologies provide unprecedented opportunities for
epigenetic biomarker development. Particularly the DNA methylation pattern—which is …

Cancer has a high mortality rate across the globe, and tissue biopsy remains the gold
standard for tumor diagnosis due to its high level of laboratory standardization, good …

An effective blood-based method for the diagnosis of colorectal cancer has not yet been
developed. Molecular alterations of immune cells occur early in tumorigenesis, providing the …

Background Racial/ethnic disparities in health reflect a combination of genetic and
environmental causes, and DNA methylation may be an important mediator. We compared …

Increased understanding of the phenotype and genotype abnormalities associated with
cancer including cytogenetic, immune and molecular features has facilitated development of …

Background Cell-type specific DNA methylation (DNAm) can be employed to determine the
numbers of leukocyte subsets in blood. In contrast to conventional methods for leukocyte …

Background Differential leukocyte counts are usually measured based on cellular
morphology or surface marker expression. It has recently been shown that leukocyte counts …

PURPOSE AML is a hematologic cancer that is clinically heterogeneous, with a wide range
of clinical outcomes. DNA methylation changes are a hallmark of AML but are not routinely …

Background: DNA methylation is an important epigenetic modification, among which 5-
methylcytosine methylation (5mC) is generally associated with tumorigenesis. Nonetheless …