Neuronal Hippo signaling: From development to diseases
Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …
Quiescent neural stem cells for brain repair and regeneration: lessons from model systems
Neural stem cells (NSCs) are multipotent progenitors that are responsible for producing all
of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside …
of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside …
Cryo-EM structure of the Hippo signaling integrator human STRIPAK
The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, multisubunit
protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the …
protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the …
Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers
L An, Z Cao, P Nie, H Zhang, Z Tong… - The Journal of …, 2022 - Am Soc Clin Investig
The striatin-interacting phosphatase and kinase (STRIPAK) complexes integrate
extracellular stimuli that result in intracellular activities. Previously, we discovered that …
extracellular stimuli that result in intracellular activities. Previously, we discovered that …
Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons
C Song, K Broadie - … of the National Academy of Sciences, 2023 - National Acad Sciences
In the developmental remodeling of brain circuits, neurons are removed by glial
phagocytosis to optimize adult behavior. Fragile X mental retardation protein (FMRP) …
phagocytosis to optimize adult behavior. Fragile X mental retardation protein (FMRP) …
Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling
The transitioning of neural stem cells (NSCs) between quiescent and proliferative states is
fundamental for brain development and homeostasis. Defects in NSC reactivation are …
fundamental for brain development and homeostasis. Defects in NSC reactivation are …
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease
I Verbinnen, P Vaneynde, S Reynhout… - Biochemical Society …, 2021 - portlandpress.com
By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse
tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in …
tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in …
[HTML][HTML] MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway
L An, P Nie, M Chen, Y Tang, H Zhang… - Journal of Experimental …, 2020 - rupress.org
Hyperactivation of YAP has been commonly associated with tumorigenesis, and emerging
evidence hints at multilayered Hippo-independent regulations of YAP. In this study, we …
evidence hints at multilayered Hippo-independent regulations of YAP. In this study, we …
Waking up quiescent neural stem cells: molecular mechanisms and implications in neurodevelopmental disorders
WY Ding, J Huang, H Wang - PLoS genetics, 2020 - journals.plos.org
Neural stem cells (NSCs) are crucial for development, regeneration, and repair of the
nervous system. Most NSCs in mammalian adult brains are quiescent, but in response to …
nervous system. Most NSCs in mammalian adult brains are quiescent, but in response to …
Recent Research Advances on the Hippo‐Yki Pathway of Crustaceans: Current Knowledge and Potential Applications in Crustacean Aquaculture
L Yang, Y Gan, H Deng, J He, X Xu - Reviews in Aquaculture, 2025 - Wiley Online Library
ABSTRACT The Hippo‐YAP/Yki pathway is critical for the regulation of physiological
responses in various biological processes from invertebrates to mammals. Crustaceans, in …
responses in various biological processes from invertebrates to mammals. Crustaceans, in …