Lines of evidence coming from many branches of neuroscience indicate that anxiety
disorders arise from a dysfunction in the modulation of brain circuits which regulate …

Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

GABA A receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

GABAA (γ-aminobutyric acid type A) receptors mediate most of the'fast'synaptic inhibition in
the mammalian brain and are targeted by many clinically important drugs. Certain naturally …

Certain metabolites of progesterone and deoxycorticosterone are established as potent and
selective positive allosteric modulators of the γ-aminobutyric acid type A (GABAA) receptor …

Local production of neurosteroids such as progesterone and allopregnanolone confers
neuroprotection in central nervous system (CNS) inflammatory diseases. The mitochondrial …

Certain naturally occurring pregnane steroids act in a nongenomic manner to potently and
selectively enhance the interaction of the inhibitory neurotransmitter GABA with the GABAA …

Abstract Adjustment Disorders With Anxiety (ADWA) account for almost 10% of
psychologically motivated consultations in primary care. The aim of this double‐blind …

In the past decades considerable evidence has emerged that so-called neuroactive steroids
do not only act as transcriptional factors in the regulation of gene expression but may also …

The utility and safety of postmenopausal hormone replacement therapy has recently been
put into question by large clinical trials. Their outcome has been extensively commented …