Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Purpose Clonal hematopoiesis of indeterminate potential (CHIP) occurs in the blood of
approximately 20% of older persons. CHIP is linked to an increased risk of hematologic …

Traditional risk factors are incompletely predictive of cardiovascular disease development, a
leading cause of death in the elderly. Recent epidemiological studies have shown that …

After antigen encounter by CD4+ T cells, polarizing cytokines induce the expression of
master regulators that control differentiation. Inactivation of the histone methyltransferase …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP), defined as the presence of a
somatic mutation in the peripheral blood at a variant allele frequency (VAF)≥ 2%, affects at …

Increasing evidence shows that conventional cardiovascular risk factors are incompletely
predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there …

DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved
in the pathogenesis of a variety of hematological diseases and in regulating the function of …

Clonal hematopoiesis driven by DNMT3A and TET2 mutations: ro... : Current Opinion in
Hematology Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in …