Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

Recent developments in sequencing technologies, the computer and data sciences, as well
as increasingly high-throughput immunological measurements have made it possible to …

Advances in single-cell RNA sequencing (scRNA-seq) techniques have accelerated
functional interpretation of disease-associated variants discovered from genome-wide …

Human organoids recapitulate the cell type diversity and function of their primary organs
holding tremendous potentials for basic and translational research. Advances in single‐cell …

Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) is
being increasingly used to study gene regulation. However, major analytical gaps limit its …

Introduction The clinical manifestations of acute severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) …

COVID-19 is characterized by systemic pro-inflammatory shifts with the development of
serious alterations in the functioning of the immune system. Investigations of the gene …

During the coronavirus disease 2019 (COVID-19) pandemic, large differences in
susceptibility and mortality due to severe acute respiratory syndrome coronavirus 2 (SARS …

To elucidate host response elements that define impending decompensation during SARS-
CoV-2 infection, we enrolled subjects hospitalized with COVID-19 who were matched for …

MotifbreakR is a software tool that scans genetic variants against position weight matrices of
transcription factors (TF) to determine the potential for the disruption of TF binding at the site …