The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
As aging societies in the western world face a growing prevalence of vascular cognitive
impairment and Alzheimer's disease (AD), understanding their underlying causes and …
impairment and Alzheimer's disease (AD), understanding their underlying causes and …
Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain
Whole brain irradiation (WBI), a commonly employed therapy for multiple brain metastases
and as a prophylactic measure after cerebral metastasis resection, is associated with a …
and as a prophylactic measure after cerebral metastasis resection, is associated with a …
Current dilemma and future directions over prophylactic cranial irradiation in SCLC: a systematic review in MRI and immunotherapy era
L Tang, G Tian, N Li - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Small cell lung cancer (SCLC) is the most malignant pathological type of lung cancer with
the highest mortality, and the incidence of brain metastasis (BM) is in high frequency. So far …
the highest mortality, and the incidence of brain metastasis (BM) is in high frequency. So far …
Endothelial deficiency of insulin‐like growth factor‐1 receptor leads to blood–brain barrier disruption and accelerated endothelial senescence in mice, mimicking …
Introduction Age‐related blood–brain barrier (BBB) disruption, cerebromicrovascular
senescence, and microvascular rarefaction substantially contribute to the pathogenesis of …
senescence, and microvascular rarefaction substantially contribute to the pathogenesis of …
Cranial irradiation disrupts homeostatic microglial dynamic behavior
AO Strohm, C Johnston, E Hernady, B Marples… - Journal of …, 2024 - Springer
Cranial irradiation causes cognitive deficits that are in part mediated by microglia, the
resident immune cells of the brain. Microglia are highly reactive, exhibiting changes in …
resident immune cells of the brain. Microglia are highly reactive, exhibiting changes in …
Whole brain irradiation–induced endothelial dysfunction in the mouse brain
Whole brain irradiation (WBI), also known as whole brain radiation therapy (WBRT), is a well-
established treatment for multiple brain metastases and as a preventive measure to reduce …
established treatment for multiple brain metastases and as a preventive measure to reduce …
Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and …
Hair graying, also known as canities or achromotrichia, is a natural phenomenon associated
with aging and is influenced by external factors such as stress, environmental toxicants, and …
with aging and is influenced by external factors such as stress, environmental toxicants, and …
Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice
Cognitive dysfunction following radiotherapy (RT) is one of the most common complications
associated with RT delivered to the brain, but the precise mechanisms behind this …
associated with RT delivered to the brain, but the precise mechanisms behind this …
[HTML][HTML] Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science
L Yang, P Chen, X Wen, Q Zhao - Theranostics, 2025 - pmc.ncbi.nlm.nih.gov
Brain diseases are a leading cause of disability and death worldwide. Early detection can
lead to earlier intervention and better outcomes for patients. In recent years, optical …
lead to earlier intervention and better outcomes for patients. In recent years, optical …
Radiation-Induced Macrovessel/Microvessel Disease
Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet
challenges persist because damage to normal tissue through direct impact of radiation or …
challenges persist because damage to normal tissue through direct impact of radiation or …